Police and emergency crews were called to the 600 block of West 26th Street around 9p.m. for that crash.
According to police, two people were struck by a westbound vehicle; both were taken to UPMC Hamot for treatment of serious injuries.
One of the victims died from injuries suffered in the crash.
Erie police closed a section of West 26th Street while they were on scene.
The investigation into a cause is underway.
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