So far police have only described the men as black, dressed in dark clothing.
Twenty-year-old Alexis Xavier Mook-Colon was pronounced dead at the scene of the shootings on Norman Avenue in Ashtabula.
His mother, 43-year-old Lydia Aviles died at Cleveland Metro Hospital.
A third person, Benny Mook-Colon is in critical condition.
He is the brother and son of the two other victims.
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